Fulminant Type 1 Diabetes Mellitus Associated with Coxsackie Virus Type A2 Infection: A Case Report and Literature Review

Nobumasa Ohara; Masanori Kaneko; Takeaki Nishibori; Kazuhiro Sato; Tatsuo Furukawa; Tadashi Koike; Hirohito Sone; Kenzo Kaneko; Kyuzi Kamoi

doi:10.2169/internalmedicine.55.5292

CASE REPORTS

Fulminant Type 1 Diabetes Mellitus Associated with Coxsackie Virus Type A2 Infection: A Case Report and Literature Review

Nobumasa Ohara, Masanori Kaneko, Takeaki Nishibori, Kazuhiro Sato, Tatsuo Furukawa, Tadashi Koike, Hirohito Sone, Kenzo Kaneko, Kyuzi Kamoi

Author information

Nobumasa Ohara
Department of Endocrinology and Metabolism, Nagaoka Red Cross Hospital, Japan
Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine, Japan
Masanori Kaneko
Department of Endocrinology and Metabolism, Nagaoka Red Cross Hospital, Japan
Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine, Japan
Takeaki Nishibori
Department of Infectious Disease, Nagaoka Red Cross Hospital, Japan
Kazuhiro Sato
Department of Respiratory Medicine, Nagaoka Red Cross Hospital, Japan
Tatsuo Furukawa
Department of Hematology, Nagaoka Red Cross Hospital, Japan
Tadashi Koike
Department of Hematology, Nagaoka Red Cross Hospital, Japan
Hirohito Sone
Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine, Japan
Kenzo Kaneko
Department of Endocrinology and Metabolism, Nagaoka Red Cross Hospital, Japan
Kyuzi Kamoi
Center of Diabetes, Endocrinology and Metabolism, Joetsu General Hospital, Japan

Keywords: fulminant type 1 diabetes mellitus, Coxsackie virus A2, common cold, antiviral antibody, pancreatic enzyme, insulin therapy

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 6 Pages 643-646

DOI https://doi.org/10.2169/internalmedicine.55.5292

Details

Abstract

A 65-year-old Japanese man presented to our hospital in June 2013 with a 6-day history of fever and fatigue, a 24-h history of thirst, and polyuria. His temperature was 37.8°C and he was alert. However, laboratory tests revealed severe hyperglycemia, undetectable C-peptide levels, and diabetic ketoacidosis. Serum antibody testing confirmed a Coxsackie virus A2 infection. A variety of viral infections are reported to be involved in the development of fulminant type 1 diabetes mellitus (FT1D). Our patient is the first reported case of FT1D associated with Coxsackie virus A2 infection and supports the etiological role of common viral infections in FT1D.

Corresponding author

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