Premature Atherosclerosis in a Japanese Diabetic Patient with Atypical Familial Partial Lipodystrophy and Hypertriglyceridemia

Masanori Iwanishi; Ken Ebihara; Toru Kusakabe; Shinji Harada; Jun Ito-Kobayashi; Atsushi Tsuji; Kiminori Hosoda; Kazuwa Nakao

doi:10.2169/internalmedicine.51.7461

CASE REPORTS

Premature Atherosclerosis in a Japanese Diabetic Patient with Atypical Familial Partial Lipodystrophy and Hypertriglyceridemia

Masanori Iwanishi, Ken Ebihara, Toru Kusakabe, Shinji Harada, Jun Ito-Kobayashi, Atsushi Tsuji, Kiminori Hosoda, Kazuwa Nakao

Author information

Masanori Iwanishi
Diabetes and Endocrine Division, Kusatsu General Hospital, Japan
Ken Ebihara
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
Toru Kusakabe
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
Shinji Harada
Diabetes and Endocrine Division, Kusatsu General Hospital, Japan
Jun Ito-Kobayashi
Diabetes and Endocrine Division, Kusatsu General Hospital, Japan
Atsushi Tsuji
Department of Neurosurgery, Kusatsu General Hospital, Japan
Kiminori Hosoda
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
Kazuwa Nakao
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan

Keywords: familial partial lipodystrophy (FPL), premature atherosclerosis, insulin resistance, pioglitazone

JOURNAL OPEN ACCESS

2012 Volume 51 Issue 18 Pages 2573-2579

DOI https://doi.org/10.2169/internalmedicine.51.7461

Details

Abstract

We herein report a case of premature atherosclerosis in a patient with familial partial lipodystrophy (FPL), diabetes mellitus, hypertension and hypertriglyceridemia. Sequencing of the candidate genes LMNA, PPARG and CAV1 associated with FPL revealed no genetic abnormalities, which indicated the activity of a novel gene in this patient. The patient's son showed milder fat loss and similar fat distribution compared to the proband; however, the son showed no signs of any atherosclerotic disease. Although a cluster of atherogenic risk factors is likely to be the primary causes of atherosclerosis in our patient, other factors, including an unknown gene associated with FPL, the severity of fat loss and gender, might affect the development of atherosclerosis.

Corresponding author

Register with J-STAGE for free!