Pharmacological Characterization of Standard Analgesics on Oxaliplatin-Induced Acute Cold Hypersensitivity in Mice

Meng Zhao; Saki Nakamura; Takahito Miyake; Kanako So; Hisashi Shirakawa; Shogo Tokuyama; Minoru Narita; Takayuki Nakagawa; Shuji Kaneko

doi:10.1254/jphs.13249SC

Short Communication

Pharmacological Characterization of Standard Analgesics on Oxaliplatin-Induced Acute Cold Hypersensitivity in Mice

Meng Zhao, Saki Nakamura, Takahito Miyake, Kanako So, Hisashi Shirakawa, Shogo Tokuyama, Minoru Narita, Takayuki Nakagawa, Shuji Kaneko

Author information

Meng Zhao
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
Saki Nakamura
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
Takahito Miyake
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
Kanako So
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
Hisashi Shirakawa
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
Shogo Tokuyama
Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, Japan
Research Promotion Committee, Japanese Society for Pharmaceutical Palliative Care and Sciences, Japan
Minoru Narita
Research Promotion Committee, Japanese Society for Pharmaceutical Palliative Care and Sciences, Japan
Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan
Takayuki Nakagawa
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
Research Promotion Committee, Japanese Society for Pharmaceutical Palliative Care and Sciences, Japan
Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Japan
Shuji Kaneko
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan

Keywords: oxaliplatin, acute peripheral neuropathy, analgesic

JOURNAL FREE ACCESS

2014 Volume 124 Issue 4 Pages 514-517

DOI https://doi.org/10.1254/jphs.13249SC

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Abstract

Oxaliplatin, a platinum-based chemotherapeutic agent, causes an acute peripheral neuropathy triggered by cold in almost all patients during or within hours after its infusion. We recently reported that a single administration of oxaliplatin induced cold hypersensitivity 2 h after the administration in mice. In this study, we examined whether standard analgesics relieve the oxaliplatin-induced acute cold hypersensitivity. Gabapentin, tramadol, mexiletine, and calcium gluconate significantly inhibited and morphine and milnacipran decreased the acute cold hypersensitivity, while diclofenac and amitriptyline had no effects. These results suggest that gabapentin, tramadol, mexiletine, and calcium gluconate are effective against oxaliplatin-induced acute peripheral neuropathy.

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